Endocrine Abstracts

Reports of pregnancy in acromegalic women are uncommon.Case 1: Patient K., 25-year-old., 01/04/2008 – transsphenoidal adenomectomy in connection with active acromegaly (GH/OGTT – 47.2–64.0–38.0–29.6–28.7 ng/ml; macroadenoma 19×14×12 mm with compression of optic chiasm). Postoperative remission of the disease, recovery of menstrual function without additional therapy. At the end of August 2008 the patient became pre...

Acromegaly is frequently associated with tumor development of various organs, mostly with cancer of colon and thyroid gland while the development of gastric cancer is a very rare condition.We observed a 33-years-old woman with mild clinical signs of acromegaly. The diagnosis was confirmed by laboratory tests (increased levels of IGF1 and growth hormone – 573 ng/ml and 9.8 ng/ml respectively) and MRI (supra-infra-latero-cellary pituitary adenoma, 9&#...

Introduction: The oxidative stress is supposed to be key factor in multiple diseases.The aim of the study was to examine the effects of excessive GH secretion on the blood antioxidant system: total antioxidant capacity (TAC) of plasma; superoxide dismutase (SOD) and catalase activities (CAT); ceruloplasmin (CP); non-protein thiol (NT), and level of thiobarbituric acid reactive substances (TBARS).Materials: Eleven patients with acti...

The study analyses direct postoperative and long-term results of surgical treatment of ACTH-secreting pituitary adenomas in 158 patients, operated between 2004 and 2009. There were 143 (91%) female and 15 (9%) male. The mean age of the patients was 36 years, S.D. 10.7. In all patients the diagnosis of Cushing’s disease was confirmed by high dose dexamethasone suppression test. Preoperative hormonal evaluation: ACTH (0800 h), pg/ml (Me-78.5 (50.5 (25th perce...

Prospective non-comparable randomized clinical investigation of GH/IGH-1 control and tumor growth reduction in active acromegalic patients on Octreotide-LAR is presented. Fifty patients (pts) with newly diagnosed acromegaly (primary teratment, group 1; mean age 47.8±13.9 years old) and 39 pts after previous surgical and/or radiological treatment (secondary treatment, group 2; mean age 48.1±12.2 years old) were treated with Ocrteotide LAR 20–40 mg every 4 weeks, ...

Introduction: The Russian Registry of patients with tumors of the hypothalamic–pituitary region (OGGO) is a national registry founded in 2004 by Russian society for Endocrinology and Endocrinology Research Centre as a patient registry for acromegaly, in 2006 it was expanded to collect information on all lesions of the hypothalamic–pituitary region, in 2010 the first fully electronic version and in 2013 a new upgraded electronic online version were implemented. At thi...